Viral suppression of RNA silencing: 2b wins the Golden Fleece by defeating Argonaute
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چکیده
منابع مشابه
Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins
The Bunyaviridae is a family of arboviruses including both plant- and vertebrate-infecting representatives. The Tospovirus genus accommodates plant-infecting bunyaviruses, which not only replicate in their plant host, but also in their insect thrips vector during persistent propagative transmission. For this reason, they are generally assumed to encounter antiviral RNA silencing in plants and i...
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We found that Sweet potato feathery mottle virus (SPFMV) P1, a close homologue of Sweet potato mild mottle virus P1, did not have any silencing suppressor activity. Remodeling the Argonaute (AGO) binding domain of SPFMV P1 by the introduction of two additional WG/GW motifs converted it to a silencing suppressor with AGO binding capacity. To our knowledge, this is the first instance of the trans...
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In most eukaryotes, RNA silencing is an adaptive immune system regulating key biological processes including antiviral defense. To evade this response, viruses of plants, worms and insects have evolved viral suppressors of RNA silencing proteins (VSRs). Various VSRs, such as P1 from Sweet potato mild mottle virus (SPMMV), inhibit the activity of RNA-induced silencing complexes (RISCs) including...
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The 35S promoter of cauliflower mosaic virus and that of other plant pararetroviruses gives rise to an RNA, which is both a pre-genome and a polycistronic mRNA. The 600 nucleotide long very structured leader of this RNA is also transcribed separately. The resulting 8S RNA is then converted to a double strand giving rise to a huge set of siRNAs, which suppress silencing. In this Mini-Review I di...
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The total genome sequence of the archaeon Methanococcus jannaschii completes the trilogy of genomes for the three domains of life-Archaea, Bacteria and Eucarya. It will have far-reaching consequences for evolutionary studies and for the way in which experimental biology is performed.
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ژورنال
عنوان ژورنال: BioEssays
سال: 2007
ISSN: 0265-9247,1521-1878
DOI: 10.1002/bies.20556